Screen mesh blockage is a common issue in industrial and daily use, significantly impacting screening efficiency and equipment lifespan. This guide systematically covers the three main causes—material characteristics, improper equipment operation, and environmental factors—and details various cleaning methods, including physical, chemical, and special scenario techniques. It also highlights key precautions during cleaning, such as avoiding screen damage and chemical residues, and offers comprehensive prevention strategies from material pretreatment to equipment maintenance. With this guide, users can manage the entire process from emergency handling to long-term protection, effectively reducing blockages and enhancing screen performance.