Polyurethane screen panels are essential components in industrial screening, with performance heavily reliant on the choice between MDI and TDI raw materials. This article systematically compares the differences in molecular structure, reaction characteristics, and practical applications of MDI and TDI, covering scenarios such as high-wear mining screening, harsh operational environments, and flexible agricultural screening. By analyzing core advantages and suitable conditions, it assists readers in selecting the appropriate panel type based on specific needs, thereby enhancing screening efficiency and equipment lifespan. The content is based on real industrial data and case studies, offering practical insights for engineers and decision-makers.